Specialty Chemicals

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Catalog Number: 26511- L-Ergothioneine (100mg)

Class:Natural Product
Chemical class: 2-thio-imidazole, amino acid.
Introduction:L-Ergo™ is synthetically derived L-Ergothioneine. It is a ubiquitous, naturally occurring and sulfur-containing intracellular antioxidant found in most plants and animals.
Source:Naturally biosynthesized by fungi and mycobacterium in the soil, subsequently assimilated by plant roots. Cannot be synthesized by animal species, historically available only from dietary sources. Commercial availability: Microbiological route, (Miyoshi et al, 1968)1 low yield and purity. OXIS' chemical route, (patent # 5,43 8,151)2 high yield and purity.
Properties:98 % pure, white crystalline solid.
Water soluble (Solubility limit of 0.9M at Room Temp.)
Does not auto-oxidize at physiological pH. Also very stable to strong alkali conditions.
Activity:Potent antioxidant3,4 Directly scavenges reactive oxygen species Activates key antioxidant enzymes. Chelates metallic cations. Powerful peroxynitrite (ONOO-) scavenger5 shown to reduce oxidative damage to human neuronal cell line N-18-RE-105 in the presence of ONOO-.6 Metabolic regulation Stimulates RBC energy production. Stimulates normal respiratory energy production.
Application:Dietary / Food supplement.
Dermal Protectant - Sunscreens/protective cosmetics
Ophthalmic - Topical, replenish less during cataract development.
Organ preservation - increase viability of organs used in transplants.
Safety:Acute Toxicity (OXIS 1997)7: Adult male rats single dosed at 62.5, 125, 250 and 500mg/kg. Followed 14 days. Chronic Toxicity (OXIS,1997)8 : Dosed once a day at 50 and 200mg/kg for 14 days
Results:
No signs of toxicity as measured by mortality, clinical observation, variation in body weight or hematological and biochemical parameters. Further studies in progress.
Position:U.S. Patent #5,438,151 is a process patent for the synthesis of pure L-(+)-ergothioneine. Issued August, 1995. Patent Assignee, OXIS International, Inc. 

Catalog Number: 26515 - 4-Hydroxy-non-enal-diethylacetal

Spec.:100 mg

Classification: Oxidative Stress (Bio-Marker)

Catalog Number: 26526 - 4-hydroxy-2-nonenal

Spec.:1 mg

Classification: Lipid Peroxidation (Bio-Marker)

Catalog Number: 26532 - MnTBAP

Spec.:25 mg

Classification: Oxidative Stress (Antioxidant)

Catalog Number: 26544 - Caffeic acid phenethyl ester (CAPE)

Spec.:25 mg

Classification: Oxidative Stress (Antioxidant)

Catalog Number: 28712 - Arachidonic Acid, Porcine Liver, Sodium Salt

Spec.: 100 mg

Classification: Nitric Oxide Stimulators    

Catalog Number: 29124 - L-NIL, Dihydrochloride

Spec.: 10 mg

Classification: Nitric Oxide & Nitric Oxide Synthase Inhibitors    

Catalog Number: 29126 - 7-Nitroindazole,

 Spec.: 100 mg

Classification: Nitric Oxide & Nitric Oxide Synthase Inhibitors 

Catalog Number: 29135 - 7-Nitroindazole, 3-Bromo Sodium Salt

Spec.: 5 mg

Classification: Nitric Oxide & Nitric Oxide Synthase Inhibitors 

Catalog Number: 29138 - N-Nitro-arginine Methyl Ester, Hydrochloride

Spec.: 200 mg

Classification: Nitric Oxide & Nitric Oxide Synthase Inhibitors 

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Catalog Number: 30117 - (+-)-S-Nitroso-N-Acetylpenicillamine

Spec.: 20 mg

Classification: Nitric Oxide Donors & Precursors 

Catalog Number: 50125 - (+-)-S-Nitroso-N-Acetylpenicillamine

Spec.: 5 mg

Classification: Nitric Oxide Donors & Precursors 

Catalog Number: 31000 - M2VP (1-methyl-2-vinyl-pyridinium triflouomethane-sulfonate)

Spec.: 5 mg

Classification: Glutathione Reduced Scavengers 

Catalog Number: 31110 - Carboxy-PTIO

Spec.: 10 mg

Classification: Nitric Oxide Scavengers

Catalog Number: 31111 - Hemoglobin, Bovine Erythrocyte

Spec.: 5 g

Classification: Nitric Oxide Scavengers

Catalog Number: 32110 - Nitric Oxide Synthase (599-613) Blocking Peptide, Bovine Endothelial Cell

Spec.: 100 ug

Classification: Nitric Oxide Blocking Peptides

Catalog Number: 32111 - Inducible Nitric Oxide Synthase (1131-1144) Blocking Peptide, Mouse Macropha

Spec.: 100 ug

Classification: Nitric Oxide Blocking Peptides

Catalog Number: 33133 - Trolox

Spec.: 500 mg

Classification: Peroxynitrite & Peroxynitrite Scavengers

Catalog Number: 34112 - Zinc (II) Protoporphyrin IX

Spec.: 25 mg

Classification: Guanylyl Cyclase Inhibitors

Catalog Number: 60100 - Glutathione Oxidized disodium salt

Spec.: 100 mg

Classification: Oxidative Stress (Bio-Marker)

Catalog Number: 60200 - Glutathione reduced

Spec.: 10 mg

Classification: Oxidative Stress (Bio-Marker)

Catalog Number: 60300 - 4-chloro-1-methyl-7-trifluromethyl-quinolinium methylsulfate

Spec.: 100 mg

Classification: GSH Indicator    

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Catalog Number: 60400 - NADPH (β-Nicotinamide adenine dinucleotide 2′-phosphate reduced tetrasodium

Spec.: 100 mg

Classification: Bio-cofactor      

Catalog Number: 60500 - β-Nicotinamide adenine dinucleotide phosphate sodium salt hydrate

Spec.: 100 mg

Classification: Bio-cofactor 

Catalog Number: 60600 - TMB (3,3′,5,5′-Tetramethylbenzidine dihydrochloride hydrate)

Spec.: 100 mg

Classification: Sensitive Chromogen Substrate